T cell ageing: effects of age on development, survival & function.
Indian J Med Res
; 138(5): 595-608, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24434315
ABSTRACT
Age associated decline of the immune system continues to be a major health concern. All components of innate and adaptive immunity are adversely affected to lesser or greater extent by ageing resulting in an overall decline of immunocompetence. As a result in the aged population, there is increased susceptibility to infection, poor responses to vaccination, and increased incidence of autoreactivity. There is an increasing focus on the role of T cells during ageing because of their impact on the overall immune responses. A steady decline in the production of fresh naïve T cells, more restricted T cell receptor (TCR) repertoire and weak activation of T cells are some of the effects of ageing. In this review we summarize our present understanding of the effects of ageing on naïve CD4 T cells and potential approaches for therapeutic interventions to restore protective immunity in the aged population.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Linfócitos T CD4-Positivos
/
Imunidade Adaptativa
/
Imunidade Inata
Limite:
Humans
Idioma:
En
Revista:
Indian J Med Res
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Índia