Pineal region tumors: Clinical symptoms and syndromes.
Neurochirurgie
; 61(2-3): 106-12, 2015.
Article
em En
| MEDLINE
| ID: mdl-24439798
ABSTRACT
The present paper investigates the clinical picture and the different clinical signs that reveal pineal region tumors or appear during the course of the follow-up. Biological malignancy and tumor extension determine the semiology and its setting up mode. Typical endocrine signs, dominated by abnormal puberty development, are frequently a part of the clinical scene. Bifocal or ectopic localization in the hypothalamic-pituitary region is accompanied by other endocrine signs such as ante- or post-pituitary insufficiencies which occur several months or even years after the first neurological signs appear. Due to a mass syndrome and obstructive hydrocephalus, intracranial hypertension signs are frequent but unspecific. A careful ophthalmologic examination is essential to search upward gaze paralysis and other signs of the Parinaud's tetrad or pentad. Midbrain dysfunction, including extrinsic aqueduct stenosis, are also prevalent. Except for abnormal pubertal signs, hyper-melatoninemia (secretory tumors) or a-hypo-melatoninemia (tumors destructing pineal) generally remains dormant. Some patients present sleep problems such as narcolepsy or sleepiness during the daytime as well as behavioral problems. This suggests a hypothalamic extension rather than a true consequence of melatonin secretion anomalies. Similarly, some patients may present signs of a "pinealectomized" syndrome, including (cluster) headaches, tiredness, eventually responsive to melatonin.
Palavras-chave
Adultes; Clinical signs; Dysfonction endocrinienne; Endocrine dysfunction; Enfants; Hypertension intracrânienne; Intracranial hypertension; Melatonin; Mélatonine; Narcolepsie secondaire; Narcolepsy; Ophthalmological signs; Parinaud's syndrome; Pineal region tumors; Signes cliniques; Signes ophtalmologiques; Syndrome de Parinaud; Tumeurs de la région pinéale
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glândula Pineal
/
Pinealoma
/
Neoplasias Encefálicas
/
Hipertensão Intracraniana
/
Hidrocefalia
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neurochirurgie
Ano de publicação:
2015
Tipo de documento:
Article