Serotonin-1A receptor CC genotype is associated with persistent depression related to interferon-alpha in hepatitis C patients.
Gen Hosp Psychiatry
; 36(3): 255-60, 2014.
Article
em En
| MEDLINE
| ID: mdl-24462335
ABSTRACT
OBJECTIVE:
The aim of this study is to investigate the development of depression during interferon-alpha (IFN-α) therapy and the variations in the expression of the serotonin receptor (5-HTR) and transporter (5-HTT) in hepatitis C patients.METHOD:
Hepatitis C patients (n=277) were given the Mini International Neuropsychiatric Interview at the end of IFN-α therapy. Three polymorphisms were genotyped the serotonin transporter repeat length polymorphic region [5-HTT gene-linked polymorphic region (5-HTTLPR)], as well as SNPs rs25531 and rs6295, located within the 5-HTTLPR and the transcriptional control region of the 5-HTR1A gene, respectively.RESULTS:
The diagnosis of current depression, which was associated with IFN-α-related depression (P<.001), demonstrated a statistically significant association with the CC genotype of the 5-HTR1A gene (odds ratio=5.57, 95% confidence interval=1.61-19.24, P=.007).CONCLUSIONS:
Persistent depression may represent a more specific type of IFN-α-related psychopathology. Future studies need to investigate the genetic risk factors for vulnerability associated with persistent depression. Limitations, such as the study's cross-sectional design, small sample size and retrospective assessment of IFN-α-induced depression diagnosis, must be taken into account while interpreting the results found in this study.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Interferon-alfa
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Hepatite C
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Receptor 5-HT1A de Serotonina
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Transtorno Depressivo Maior
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Proteínas da Membrana Plasmática de Transporte de Serotonina
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Gen Hosp Psychiatry
Ano de publicação:
2014
Tipo de documento:
Article