Association between endothelial nitric oxide synthase intron 4a/b polymorphism and aortic dissection.
Turk Kardiyol Dern Ars
; 42(1): 55-60, 2014 01.
Article
em En
| MEDLINE
| ID: mdl-24481096
ABSTRACT
OBJECTIVES:
The genetic risk factors that contribute to the risk of developing aortic dissection (AD) have been studied. We assessed the association of endothelial nitric oxide synthase (eNOS) gene polymorphism with AD. STUDYDESIGN:
Patients who underwent surgery with the diagnosis of AD and survived after the operation in our center between May 2007 and June 2011 were recruited retrospectively. The eNOS intron 4a/b polymorphism was determined by polymerase chain reaction (PCR) using oligonucleotide primers (sense 5'-AGGCCCTATGGTAGTGCCTTT-3'; antisense 5'-TCTCTTAGTGCTGTGGTCAC-3') that flank the region of the 27 bp VNTR in intron 4.RESULTS:
Thirty-nine patients (88%) had type A AD, while the remainder (12%) had type B AD. The distribution of eNOS4 a/b gene polymorphism differed significantly from the control group, with higher frequencies of eNOS 4a/a and 4a/b genotypes in the AD group (x(2)=7.16, p=0.03).CONCLUSION:
In this study, the distribution of eNOS genotypes differed between the AD and control groups; however, this polymorphism was not found to be an independent factor for the development of AD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Íntrons
/
Aneurisma da Aorta Torácica
/
Óxido Nítrico Sintase Tipo III
/
Dissecção Aórtica
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Turk Kardiyol Dern Ars
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Turquia