AMASS: a database for investigating protein structures.
Bioinformatics
; 30(11): 1595-600, 2014 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-24497503
ABSTRACT
MOTIVATION Modern techniques have produced many sequence annotation databases and protein structure portals, but these Web resources are rarely integrated in ways that permit straightforward exploration of protein functional residues and their co-localization. RESULTS:
We have created the AMASS database, which maps 1D sequence annotation databases to 3D protein structures with an intuitive visualization interface. Our platform also provides an analysis service that screens mass spectrometry sequence data for post-translational modifications that reside in functionally relevant locations within protein structures. The system is built on the premise that functional residues such as active sites, cancer mutations and post-translational modifications within proteins may co-localize and share common functions. AVAILABILITY AND IMPLEMENTATION AMASS database is implemented with Biopython and Apache as a freely available Web server at amass-db.org.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Conformação Proteica
/
Bases de Dados de Proteínas
Limite:
Humans
Idioma:
En
Revista:
Bioinformatics
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2014
Tipo de documento:
Article