Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines.
J Neuroimmunol
; 268(1-2): 50-7, 2014 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-24507620
ABSTRACT
Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulatory patches (LT-IS) dramatically enhances the onset and magnitude of immune responses to DNA- and protein-based vaccines for Alzheimer's disease following intradermal immunization via gene gun and conventional needles, respectively. Our studies suggest that the immune activation mediated by LT-IS offers improved potency for generating AD-specific vaccination responses that should be investigated as an adjuvant in the clinical arena.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Toxinas Bacterianas
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Adjuvantes Imunológicos
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Vacinação
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Proteínas de Escherichia coli
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Vacinas contra Alzheimer
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Enterotoxinas
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos