Evaluation of the extract of Zeyheria tuberculosa with a view to products for wound healing.
Rev Lat Am Enfermagem
; 22(1): 165-72, 2014.
Article
em En, Pt, Es
| MEDLINE
| ID: mdl-24553718
ABSTRACT
OBJECTIVES:
to evaluate the antimicrobial, cytotoxic and healing activities of the ethanolic extract of the stems of Z. tuberculosa via topical use and/or oral ingestion.METHOD:
antimicrobial assays in vitro using the disk diffusion method, the Artemia salina toxicity test, and in vivo assays with Wistar rats. From these was collected clinical, histological and biochemical data for evaluating the healing process.RESULTS:
in vitro antimicrobial testing showed activity in relation to Streptococcus pyogenes, Staphylococcus aureus and Staphylococcus epidermidis, with zones of inhibition of 18, 14 and 10 mm, respectively. The best minimum inhibitory concentration was 62.5 µg/ml for S. aureus, this bacteria being chosen for the in vitro assays. Animals treated with the ointments with the extract of Z. tuberculosa showed the best results in the reduction of the wound diameter, data confirmed by the presence of re-epithelialization in the histological samples.CONCLUSION:
the extract was shown to be promising for the continuation of studies which may identify the active ingredients responsible for the pharmacological activity and its mechanism of action in the process of wound healing, so as to develop a product which may be used as an alternate means in the repair of infected cutaneous wounds.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
Extratos Vegetais
/
Bignoniaceae
/
Fitoterapia
Tipo de estudo:
Evaluation_studies
Limite:
Animals
Idioma:
En
/
Es
/
Pt
Revista:
Rev Lat Am Enfermagem
Assunto da revista:
ENFERMAGEM
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil