Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial.
Acta Derm Venereol
; 94(5): 521-5, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24553997
ABSTRACT
This study was undertaken to evaluate the clinical efficacy, safety, and histological changes induced by dietary omega-3 fatty acid and γ-linoleic acid in acne vulgaris. A 10-week, randomised, controlled parallel dietary intervention study was performed in 45 participants with mild to moderate acne, which were allocated to either an omega-3 fatty acid group (2,000 mg of eicosapentaenoic acid and docosahexaenoic acid), a γ-linoleic acid group (borage oil containing 400 mg γ-linoleic acid), or a control group. After 10 weeks of omega-3 fatty acid or γ-linoleic acid supplementation, inflammatory and non-inflammatory acne lesions decreased significantly. Patient subjective assessment of improvement showed a similar result. Heamatoxylin & eosin staining of acne lesions demonstrated reductions in inflammation and immunohistochemical staining intensity for interleukin-8. No severe adverse effect was reported. This study shows for the first time that omega-3 fatty acid and γ-linoleic acid could be used as adjuvant treatments for acne patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Eicosapentaenoico
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Ácidos Docosa-Hexaenoicos
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Acne Vulgar
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Ácido alfa-Linolênico
/
Suplementos Nutricionais
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Acta Derm Venereol
Ano de publicação:
2014
Tipo de documento:
Article