Recent radiation within Y-chromosomal haplogroup R-M269 resulted in high Y-STR haplotype resemblance.
Ann Hum Genet
; 78(2): 92-103, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24571229
ABSTRACT
Y-chromosomal short tandem repeats (Y-STRs) are often used in addition to Y-chromosomal single-nucleotide polymorphisms (Y-SNP) to detect subtle patterns in a population genetic structure. There are, however, indications for Y-STR haplotype resemblance across different subhaplogroups within haplogroup R1b1b2 (R-M269) which may lead to erosion in the observation of the population genetic pattern. Hence the question arises whether Y-STR haplotypes are still informative beyond high-resolution Y-SNP genotyping for population genetic studies. To address this question, we genotyped the Y chromosomes of more than 1000 males originating from the West-European regions of Flanders (Belgium), North-Brabant and Limburg (the Netherlands) at the highest resolution of the current Y-SNP tree together with 38 commonly used Y-STRs. We observed high resemblance of Y-STR haplotypes between males belonging to different subhaplogroups of haplogroup R-M269. Several subhaplogroups within R-M269 could not be distinguished from each other based on differences in Y-STR haplotype variation. The most likely hypothesis to explain this similarity of Y-STR haplotypes within the population of R-M269 members is a recent radiation where various subhaplogroups originated within a relatively short time period. We conclude that high-resolution Y-SNP typing rather than Y-STR typing might be more useful to study population genetic patterns in (Western) Europe.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Repetições de Microssatélites
/
Cromossomos Humanos Y
/
População Branca
Limite:
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Ann Hum Genet
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Bélgica