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Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.
Ciceri, Pietro; Müller, Susanne; O'Mahony, Alison; Fedorov, Oleg; Filippakopoulos, Panagis; Hunt, Jeremy P; Lasater, Elisabeth A; Pallares, Gabriel; Picaud, Sarah; Wells, Christopher; Martin, Sarah; Wodicka, Lisa M; Shah, Neil P; Treiber, Daniel K; Knapp, Stefan.
Afiliação
  • Ciceri P; 1] KINOMEscan Division of DiscoveRx Corporation, San Diego, California, USA. [2].
  • Müller S; 1] Nuffield Department of Clinical Medicine, University of Oxford, Structural Genomics Consortium, Oxford, UK. [2] Nuffield Department of Clinical Medicine, University of Oxford, Target Discovery Institute (TDI), Oxford, UK. [3].
  • O'Mahony A; 1] BioSeek Division of DiscoveRx Corporation, San Francisco, California, USA. [2].
  • Fedorov O; Nuffield Department of Clinical Medicine, University of Oxford, Target Discovery Institute (TDI), Oxford, UK.
  • Filippakopoulos P; 1] Nuffield Department of Clinical Medicine, University of Oxford, Structural Genomics Consortium, Oxford, UK. [2] Nuffield Department of Clinical Medicine, University of Oxford, Ludwig Institute for Cancer Research (LICR), Oxford, UK.
  • Hunt JP; KINOMEscan Division of DiscoveRx Corporation, San Diego, California, USA.
  • Lasater EA; Division of Hematology/Oncology, University of California-San Francisco, San Francisco, California, USA.
  • Pallares G; KINOMEscan Division of DiscoveRx Corporation, San Diego, California, USA.
  • Picaud S; 1] Nuffield Department of Clinical Medicine, University of Oxford, Structural Genomics Consortium, Oxford, UK. [2] Nuffield Department of Clinical Medicine, University of Oxford, Ludwig Institute for Cancer Research (LICR), Oxford, UK.
  • Wells C; 1] Nuffield Department of Clinical Medicine, University of Oxford, Structural Genomics Consortium, Oxford, UK. [2] Nuffield Department of Clinical Medicine, University of Oxford, Target Discovery Institute (TDI), Oxford, UK.
  • Martin S; Nuffield Department of Clinical Medicine, University of Oxford, Target Discovery Institute (TDI), Oxford, UK.
  • Wodicka LM; KINOMEscan Division of DiscoveRx Corporation, San Diego, California, USA.
  • Shah NP; Division of Hematology/Oncology, University of California-San Francisco, San Francisco, California, USA.
  • Treiber DK; KINOMEscan Division of DiscoveRx Corporation, San Diego, California, USA.
  • Knapp S; 1] Nuffield Department of Clinical Medicine, University of Oxford, Structural Genomics Consortium, Oxford, UK. [2] Nuffield Department of Clinical Medicine, University of Oxford, Target Discovery Institute (TDI), Oxford, UK.
Nat Chem Biol ; 10(4): 305-12, 2014 Apr.
Article em En | MEDLINE | ID: mdl-24584101
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Protocolos de Quimioterapia Combinada Antineoplásica / Inibidores de Proteínas Quinases / Polifarmacologia Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Protocolos de Quimioterapia Combinada Antineoplásica / Inibidores de Proteínas Quinases / Polifarmacologia Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article