Obtaining real-world evidence: the Salford Lung Study.
Thorax
; 69(12): 1152-4, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-24603195
ABSTRACT
We need to assess clinical treatments in real-life settings outside of randomised controlled trials (RCTs). Pragmatic RCT (pRCT) data can supplement RCTs by providing effectiveness information to support healthcare decisions. Electronic health records can facilitate concurrent safety monitoring and data collection without direct patient contact for large randomised study populations in pRCTs. The Salford Lung Study is the world's first phase III pRCT in asthma and chronic obstructive pulmonary disease (COPD), which aims to randomise over 7000 patients. This paper describes the hurdles overcome and the enormous effort and resource required to establish this comparative effectiveness study of a prelicence intervention. GLAXOSMITHKLINE PROTOCOL HZC115151 ASTHMA STUDY CLINICALTRIALSGOV REGISTRATION NCT01706198 COPD STUDY CLINICALTRIALSGOV REGISTRATION NCT01551758.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Agonistas Adrenérgicos beta
/
Doença Pulmonar Obstrutiva Crônica
/
Glucocorticoides
Tipo de estudo:
Clinical_trials
/
Guideline
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Thorax
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Reino Unido