Aging-related differences in cerebral capillary blood flow in anesthetized rats.
Neurobiol Aging
; 35(8): 1947-55, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24612672
ABSTRACT
Age-related decreases in baseline cerebral blood flow have been measured with various imaging modalities, however, the contribution of capillary flow to this phenomenon remain to elucidate. This study used 2-photon laser scanning fluorescence microscopy to measure capillary diameter, red blood cell speed, and flux in individual capillaries in the sensory-motor cortex of 12 adult (3-month-old) and 12 old (24-month-old) male Long-Evans rats under isoflurane anesthesia. The average (± standard deviation) diameter and speed over 921 capillaries were 6.4 ± 1.4 µm and 1.3 ± 1.1 mm/s, respectively. Red blood cell speed and flux were significantly higher, by 48% and 15%, respectively, in old compared with young animals (p < 5%). The diameter also showed a similar tendency (7% higher, p = 5.7%). Furthermore, capillary hematocrit and density were significantly lower in the older group (p < 5%), by 32% and 20%, respectively.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Velocidade do Fluxo Sanguíneo
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Envelhecimento
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Capilares
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Circulação Cerebrovascular
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Anestesia
Limite:
Animals
Idioma:
En
Revista:
Neurobiol Aging
Ano de publicação:
2014
Tipo de documento:
Article