Role of interleukin-22 in liver diseases.
Inflamm Res
; 63(7): 519-25, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24623532
ABSTRACT
INTRODUCTION:
Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local intestinal inflammation among others. MATERIALS ANDMETHODS:
A PubMed and Web of Science databases search was performed for studies providing evidences on the role of IL-22 in liver diseases.CONCLUSION:
IL-22 plays an important role in ameliorating liver injury in many rodent models by targeting hepatocytes that express high levels of IL-22 receptor 1 and IL-10 receptor 2. This review concisely summarizes the role of IL-22 in the development progression of liver disease of different etiologies. It is focused mainly on the IL-22 intracellular signaling and its influence on liver diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interleucinas
/
Hepatopatias
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Inflamm Res
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China