Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

Lu, Zhonglei; Bauzon, Frederick; Fu, Hao; Cui, Jinhua; Zhao, Hongling; Nakayama, Keiko; Nakayama, Keiich I; Zhu, Liang

Lu, Zhonglei; Bauzon, Frederick; Fu, Hao; Cui, Jinhua; Zhao, Hongling; Nakayama, Keiko; Nakayama, Keiich I; Zhu, Liang.

Afiliação

Lu Z; Department of Developmental and Molecular Biology and Ophthalmology and Visual Sciences and Medicine, The Albert Einstein Comprehensive Cancer Center and Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Bauzon F; Department of Developmental and Molecular Biology and Ophthalmology and Visual Sciences and Medicine, The Albert Einstein Comprehensive Cancer Center and Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Fu H; Department of Developmental and Molecular Biology and Ophthalmology and Visual Sciences and Medicine, The Albert Einstein Comprehensive Cancer Center and Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Cui J; Department of Developmental and Molecular Biology and Ophthalmology and Visual Sciences and Medicine, The Albert Einstein Comprehensive Cancer Center and Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Zhao H; Department of Developmental and Molecular Biology and Ophthalmology and Visual Sciences and Medicine, The Albert Einstein Comprehensive Cancer Center and Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Nakayama K; Division of Cell Proliferation, ART, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Nakayama KI; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
Zhu L; Department of Developmental and Molecular Biology and Ophthalmology and Visual Sciences and Medicine, The Albert Einstein Comprehensive Cancer Center and Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Nat Commun ; 5: 3463, 2014 Mar 17.

Article em En | MEDLINE | ID: mdl-24632684

Assuntos

Apoptose; Regulação para Baixo; Fator de Transcrição E2F1/metabolismo; Neoplasias/genética; Neoplasias/metabolismo; Proteína do Retinoblastoma/deficiência; Proteínas Quinases Associadas a Fase S/metabolismo; Animais; Proliferação de Células; Fator de Transcrição E2F1/genética; Regulação Neoplásica da Expressão Gênica; Humanos; Camundongos Knockout; Neoplasias/fisiopatologia; Hipófise/metabolismo; Proteína do Retinoblastoma/genética; Proteínas Quinases Associadas a Fase S/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação para Baixo / Proteína do Retinoblastoma / Apoptose / Proteínas Quinases Associadas a Fase S / Fator de Transcrição E2F1 / Neoplasias Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

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