Simplified system to investigate alteration of retinal neurons in diabetes.
Adv Exp Med Biol
; 801: 139-43, 2014.
Article
em En
| MEDLINE
| ID: mdl-24664691
ABSTRACT
Diabetic retinopathy (DR) is traditionally considered as a microvascular complication in diabetic retinas. Emerging evidences suggest that the alteration of neuronal function and the death of retinal neurons are part of DR pathology. However, surprisingly little is known about how retinal neurons behave in DR. As diabetic animals are chronicle models that are difficult and expensive to maintain, we used a chemical hypoxia model that mimics the later stage of diabetes and investigated its potential in predicting retinal cell behaviors in diabetes in an efficient manner. In this chapter, we discuss the similarities and differences between diabetic and hypoxic models and the usefulness and limitation of the cobalt-chloride-generated hypoxia system in mice for studying retinal neurobiology in diabetes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Diabetes Mellitus Experimental
/
Retinopatia Diabética
/
Neurônios Retinianos
/
Hipóxia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos