Enhancer RNAs and regulated transcriptional programs.
Trends Biochem Sci
; 39(4): 170-82, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24674738
ABSTRACT
A large portion of the human genome is transcribed into RNAs without known protein-coding functions, far outnumbering coding transcription units. Extensive studies of long noncoding RNAs (lncRNAs) have clearly demonstrated that they can play critical roles in regulating gene expression, development, and diseases, acting both as transcriptional activators and repressors. More recently, enhancers have been found to be broadly transcribed, resulting in the production of enhancer-derived RNAs, or eRNAs. Here, we review emerging evidence suggesting that at least some eRNAs contribute to enhancer function. We discuss these findings with respect to potential mechanisms of action of eRNAs and other ncRNAs in regulated gene expression.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
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Regulação da Expressão Gênica
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Elementos Facilitadores Genéticos
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RNA não Traduzido
Limite:
Animals
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Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos