Thiosemicarbazone Cu(II) and Zn(II) complexes as potential anticancer agents: syntheses, crystal structure, DNA cleavage, cytotoxicity and apoptosis induction activity.

Shao, Jia; Ma, Zhong-Ying; Li, Ang; Liu, Ya-Hong; Xie, Cheng-Zhi; Qiang, Zhao-Yan; Xu, Jing-Yuan

Shao, Jia; Ma, Zhong-Ying; Li, Ang; Liu, Ya-Hong; Xie, Cheng-Zhi; Qiang, Zhao-Yan; Xu, Jing-Yuan.

Afiliação

Shao J; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
Ma ZY; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
Li A; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
Liu YH; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
Xie CZ; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
Qiang ZY; School of Basic Medicine, Tianjin Medical University, Tianjin 300070, PR China.
Xu JY; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China. Electronic address: xujingyuan@tmu.edu.cn.

J Inorg Biochem ; 136: 13-23, 2014 Jul.

Article em En | MEDLINE | ID: mdl-24690556

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Complexos de Coordenação/farmacologia; Cobre/química; Tiossemicarbazonas/química; Zinco/química; Antineoplásicos/síntese química; Ciclo Celular/efeitos dos fármacos; Proliferação de Células; Sobrevivência Celular/efeitos dos fármacos; Complexos de Coordenação/síntese química; Cristalografia por Raios X; Clivagem do DNA; Ensaios de Seleção de Medicamentos Antitumorais; Células HeLa; Células Hep G2; Humanos; Concentração Inibidora 50; Modelos Moleculares; Conformação Molecular; Plasmídeos/química; Espécies Reativas de Oxigênio

Palavras-chave

Apoptosis induction; Cytotoxicity; DNA cleavage; Potential anticancer agents; Thiosemicarbazone

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiossemicarbazonas / Zinco / Apoptose / Cobre / Complexos de Coordenação / Antineoplásicos Limite: Humans Idioma: En Revista: J Inorg Biochem Ano de publicação: 2014 Tipo de documento: Article

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