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Lumbrokinase from earthworm extract ameliorates second-hand smoke-induced cardiac fibrosis.
Lai, Chao-Hung; Han, Chien-Kuo; Shibu, Marthandam Asokan; Pai, Pei Ying; Ho, Tsung-Jung; Day, Cecilia Hsuan; Tsai, Fuu-Jen; Tsai, Chang-Hai; Yao, Chun-Hsu; Huang, Chih-Yang.
Afiliação
  • Lai CH; Graduate Institute of Aging Medicine, China Medical University, Taichung, Taiwan.
  • Han CK; Division of Cardiology, Department of Internal Medicine, Armed Force Taichung General Hospital, Taichung, Taiwan.
  • Shibu MA; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
  • Pai PY; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
  • Ho TJ; Division of Cardiology, China Medical University Hospital, Taichung, Taiwan.
  • Day CH; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.
  • Tsai FJ; Department of Chinese Medicine, China Medical University Beigang Hospital, Taiwan.
  • Tsai CH; Department of Nursing, MeiHo University, Pingtung, Taiwan.
  • Yao CH; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.
  • Huang CY; Department of Healthcare Administration, Asia University, Taichung, Taiwan.
Environ Toxicol ; 30(10): 1216-25, 2015 Sep.
Article em En | MEDLINE | ID: mdl-24706507
ABSTRACT
Exposure to tobacco smoke has epidemiologically been linked to the occurrence of cardiovascular disease among nonsmokers but the associated molecular events are not well elucidated yet. When Sprague Dawley rats were exposed to second-hand tobacco cigarette smoke twice a day for a 30 days period at an exposure rate of 10 cigarettes/30 min, they showed adverse effects including reduced left ventricle weight, increased cardiac damages, deteriorated cardiac features, and cardiac fibrosis. Exposure to second-hand smoking (SHS) increased the molecular markers of cardiac fibrosis such as urokinase plasminogen activator and matrix metallopeptidases. The modulations in the protein levels were led by the activation of extracellular signal-regulated kinases (ERK1/2), the transcription factor-specificity protein 1 (SP1), and the fibrogenic master switch-connective for epithelial-mesenchymal transition tissue growth factor there by indicating their effective role in SHS-induced myocardial infraction. Dilong, an edible earthworm extract used in Chinese medicine and its bioactive fibrinolytic enzyme product-lumbrokinase, when administered in rats, restricted the SHS exposure induced cardiac fibrosis and provided cardio-protection. The results show that lumbrokinase and dilong administration can efficiently prevent epidemiological incidence of cardiac disease among SHS-exposed nonsmokers.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligoquetos / Endopeptidases / Poluição por Fumaça de Tabaco / Coração / Miocárdio Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Environ Toxicol Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Taiwan

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligoquetos / Endopeptidases / Poluição por Fumaça de Tabaco / Coração / Miocárdio Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Environ Toxicol Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Taiwan