The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia.
J Renin Angiotensin Aldosterone Syst
; 16(3): 529-38, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-24737639
ABSTRACT
HYPOTHESIS/INTRODUCTION:
Preeclampsia is associated with alterations in the maternal renin-angiotensin-aldosterone system (RAAS), increased blood pressure (BP), and cardiovascular risk in the offspring. We hypothesized that preeclampsia is associated with alterations in the RAAS in the offspring that persist into adolescence. MATERIALS ANDMETHODS:
We compared components of the circulating (n = 111) and renal (n = 160) RAAS in adolescents born prematurely with very low birth weight (VLBW) of preeclamptic (PreE) and normotensive (NoHTN) pregnancies. Multivariable linear regression was used to evaluate potential confounding and intermediate variables. Analyses were stratified by sex.RESULTS:
Adjusting for race and antenatal steroid exposure, male offspring of PreE mothers had higher circulating aldosterone than those of NoHTN mothers (adjusted mean difference = 109; 95% confidence limits -9, 227 pmol/L). Further adjustment for current BMI attenuated this difference (adjusted mean difference 93; 95% confidence limits -30, 215 pmol/L).CONCLUSION:
Among male preterm VLBW infants, maternal preeclampsia is associated with increased circulating aldosterone level in adolescence, which appears to be mediated in part by higher BMI.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
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Sistema Renina-Angiotensina
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Nascimento Prematuro
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Mães
Limite:
Adolescent
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Female
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Humans
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Male
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Newborn
/
Pregnancy
Idioma:
En
Revista:
J Renin Angiotensin Aldosterone Syst
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos