[The diagnostic value of serum beta-hydroxybutyrate in diabetic ketosis or diabetic ketoacidosis].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 45(2): 270-3, 2014 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-24749355
ABSTRACT
OBJECTIVE:
To determine the diagnostic value of serum beta-hydroxybutyrate (betaOHB) in diabetic ketosis or diabetic ketoacidosis.METHODS:
We conducted a retrospective review of clinical data, in West China Hospital from May 2011 to May 2013, of 1 209 patients with non-ketosis diabetics (DM group), 262 patients with diabetic ketosis or diabetic ketoacidosis (DK/DKA group), and 480 healthy people undergoing routine medical examinations (normal control group). Logistic regression analyses and ROC curves were performed in determining the diagnostic value of betaOHB for DK/DKA.RESULTS:
The level of serum betaOHB was much higher in the DK/DKA patients than that of the participants in the DM group and normal control group (P < 0.01). The serum betaOHB turned negative earlier than urine ketone (P < 0.01) in the DK/DKA patients. The logistic regression analysis indicated that betaOHB was one of the independent risk factors for DK/DKA. The betaOHB had an area under of 0.975 in ROC curve, with 1 mmol/L [sensitivity (Sen.) 85.1%, specificity (Spe.) 95. 3%, positive predictive value (PV+) 80.36%, negative predictive value (PV-) 96.89%] as a diagnostic point for DK/DKA and 0.66 mmol/L (Sen. 95%, Spe. 89.2%, PV+ 66.41%, PV- 99.9%) as a screening point.CONCLUSION:
Diabetic patients with a level or higher than 1 mmol/L serum betaOHB can accurately predict DK/DKA. Patients with a level or lower than 0.66 mmol/L serum betaOHB are unlikely to have DK/DKA.
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Base de dados:
MEDLINE
Assunto principal:
Cetoacidose Diabética
/
Ácido 3-Hidroxibutírico
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Sichuan Da Xue Xue Bao Yi Xue Ban
Ano de publicação:
2014
Tipo de documento:
Article