What is the mechanism behind increased permeation rate of a poorly soluble drug from aqueous dispersions of an amorphous solid dispersion?

Frank, Kerstin J; Westedt, Ulrich; Rosenblatt, Karin M; Hölig, Peter; Rosenberg, Jörg; Mägerlein, Markus; Fricker, Gert; Brandl, Martin

Frank, Kerstin J; Westedt, Ulrich; Rosenblatt, Karin M; Hölig, Peter; Rosenberg, Jörg; Mägerlein, Markus; Fricker, Gert; Brandl, Martin.

Afiliação

Frank KJ; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense M, DK-5230, Denmark; Department of Pharmaceutical Technology, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, D-69120, Germany.

J Pharm Sci ; 103(6): 1779-86, 2014 Jun.

Article em En | MEDLINE | ID: mdl-24764046

Assuntos

Indazóis/farmacocinética; Ureia/análogos & derivados; Água/química; Células CACO-2; Humanos; Solubilidade; Ureia/farmacocinética

Palavras-chave

amorphous; microparticles; permeability; solid dispersion; solubility; supersaturation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ureia / Água / Indazóis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Pharm Sci Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Alemanha

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