Hippocampus: a target for estrogen action in mammalian brain.
Mol Endocrinol
; 3(7): 1165-70, 1989 Jul.
Article
em En
| MEDLINE
| ID: mdl-2477695
ABSTRACT
An analysis of the distribution of estrogen receptor (ER) via immunoenzymatic assay in the brain of ovariectomized rats reveals the presence of large amounts of ER-like immunoreactive material in the cytosol of the hippocampus a brain area described to contain little estrogen-binding activity. The protein detected in the hippocampus by the specific antibody is indistinguishable from the rat ER in its response to hormonal treatments and in its electrophoretic mobility. The presence of elevated amounts of ER in such an important part of the limbic system creates new possibilities for interpreting the role played by this sex hormone in the central nervous system of rat.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Estrogênio
/
Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Mol Endocrinol
Assunto da revista:
BIOLOGIA MOLECULAR
/
ENDOCRINOLOGIA
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Itália