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Antemortem MRI findings associated with microinfarcts at autopsy.
Raman, Mekala R; Preboske, Gregory M; Przybelski, Scott A; Gunter, Jeffrey L; Senjem, Matthew L; Vemuri, Prashanthi; Murphy, Matthew C; Murray, Melissa E; Boeve, Bradley F; Knopman, David S; Petersen, Ronald C; Parisi, Joseph E; Dickson, Dennis W; Jack, Clifford R; Kantarci, Kejal.
Afiliação
  • Raman MR; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Preboske GM; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Przybelski SA; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Gunter JL; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Senjem ML; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Vemuri P; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Murphy MC; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Murray ME; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Boeve BF; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Knopman DS; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Petersen RC; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Parisi JE; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Dickson DW; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Jack CR; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL.
  • Kantarci K; From the Departments of Neurology (M.R.R., B.F.B., D.S.K., R.C.P.), Radiology (G.M.P., J.L.G., M.L.S., P.V., M.C.M., C.R.J., K.K.), Health Sciences Research (S.A.P.), and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (M.E.M., D.W.D.), Mayo Clinic, Jacksonville, FL. k
Neurology ; 82(22): 1951-8, 2014 Jun 03.
Article em En | MEDLINE | ID: mdl-24793188
ABSTRACT

OBJECTIVE:

To determine antemortem MRI findings associated with microinfarcts at autopsy.

METHODS:

Patients with microinfarcts (n = 22) and patients without microinfarcts (n = 44) who underwent antemortem MRI were identified from a dementia clinic-based, population-based, and community clinic-based autopsy cohort. The microinfarct and no-microinfarct groups were matched on age at MRI, age at death, sex, APOE status, Mini-Mental State Examination score, and pathologic diagnosis of Alzheimer disease. Brain infarcts were assessed on fluid-attenuated inversion recovery (FLAIR) MRI. White matter hyperintensities on FLAIR MRI and hippocampal volumes on T1-weighted MRI were quantified using automated methods. A subset of subjects with microinfarcts (n = 15) and a matched group of subjects without microinfarcts (n = 15) had serial T1-weighted MRIs and were included in an analysis of global and regional brain atrophy rates using automated methods.

RESULTS:

The presence of cortical (p = 0.03) and subcortical (p = 0.02) infarcts on antemortem MRI was associated with presence of microinfarcts at autopsy. Higher numbers of cortical (p = 0.05) and subcortical (p = 0.03) infarcts on antemortem MRI were also associated with presence of microinfarcts. Presence of microinfarcts was not associated with white matter hyperintensities and cross-sectional hippocampal volume on antemortem MRI. Whole-brain and regional precuneus, motor, and somatosensory atrophy rates were higher in subjects with microinfarcts compared to subjects without microinfarcts.

CONCLUSIONS:

Microinfarcts increase brain atrophy rates independent of Alzheimer disease pathology. Association between microinfarct pathology and macroinfarcts on MRI suggests either common risk factors or a shared pathophysiology and potentially common preventive targets.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infarto Cerebral / Leucoencefalopatias / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Neurology Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infarto Cerebral / Leucoencefalopatias / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Neurology Ano de publicação: 2014 Tipo de documento: Article