Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse.
J Child Psychol Psychiatry
; 55(12): 1372-9, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-24811113
ABSTRACT
BACKGROUND:
This study's primary aim was to examine age-specific associations between GABRA2, rule breaking, problematic alcohol use, and substance abuse symptomatology. The secondary aim was to examine the extent to which rule breaking mediates the GABRA2-substance abuse relationship.METHODS:
A sample (n = 518) of primarily male (70.9%) and White (88.8%) adolescents from the Michigan Longitudinal Study was assessed from ages 11-18. Age-specific effects of GABRA2 on rule breaking, problematic alcohol use, and substance abuse symptomatology were examined using nested path models. The role of rule breaking as a mediator in the association between GABRA2 and substance abuse outcomes was tested using prospective cross-lagged path models.RESULTS:
GABRA2 is significantly (p < 0.05) associated with rule breaking in mid- to late-adolescence, but not substance abuse symptomatology across adolescence. GABRA2 effects on problematic alcohol use and substance abuse symptomatology operate largely (45.3% and 71.1%, respectively, p < 0.05) via rule breaking in midadolescence.CONCLUSIONS:
GABRA2 represents an early risk factor for an externalizing pathway to the development of problematic alcohol and drug use.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Comportamento do Adolescente
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Receptores de GABA-A
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Transtornos Relacionados ao Uso de Substâncias
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Delinquência Juvenil
Tipo de estudo:
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Child
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Female
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Humans
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Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Child Psychol Psychiatry
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos