Discovery of camphor-derived pyrazolones as 11ß-hydroxysteroid dehydrogenase type 1 inhibitors.
Bioorg Med Chem Lett
; 24(12): 2707-11, 2014 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-24815509
ABSTRACT
Starting from screening hit, (4S,7R)-1,7,8,8-tetramethyl-2-phenyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (7), we optimized the potency and pharmacokinetic properties. This led to the identification of compounds with good in vivo activity in a mouse pharmacodynamic model of inhibition of 11ßHSD1.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cânfora
/
11-beta-Hidroxiesteroide Desidrogenase Tipo 1
/
Pirazolonas
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Inibidores Enzimáticos
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Descoberta de Drogas
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article