Molecular characterization, expression profiles, and analysis of Qinchuan cattle SIRT1 gene association with meat quality and body measurement traits (Bos taurus).
Mol Biol Rep
; 41(8): 5237-46, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24828021
ABSTRACT
Silent information regulator (SIRT1), was closely associated with senescence, metabolism, and apoptosis. The objective of this study was to investigate whether SIRT1 gene could be used as a candidate gene in the breeding process of Qinchuan cattle. Via sequencing technology conducted in 453 individuals of Qinchuan cattle, single nucleotide polymorphisms (G25764A, A25846G, and T25868C) with 5 haplotypes and 6 combined genotypes in 3' untranslated region of SIRT1 gene were identified. In addition, three loci were significantly associated with some of the body measurements and meat quality traits in Qinchuan cattle (P < 0.05), and the H2H2 (GG-AA-CC) diplotypes had better performance than other combinations in Qinchuan cattle. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bovinos
/
Sirtuína 1
/
Transcriptoma
/
Carne
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Mol Biol Rep
Ano de publicação:
2014
Tipo de documento:
Article