Specificity and catalytic mechanism in family 5 uracil DNA glycosylase.

Xia, Bo; Liu, Yinling; Li, Wei; Brice, Allyn R; Dominy, Brian N; Cao, Weiguo

Xia, Bo; Liu, Yinling; Li, Wei; Brice, Allyn R; Dominy, Brian N; Cao, Weiguo.

Afiliação

Xia B; From the Department of Genetics and Biochemistry, South Carolina Experiment Station and.
Liu Y; the Department of Chemistry, Clemson University, Clemson, South Carolina 29634.
Li W; From the Department of Genetics and Biochemistry, South Carolina Experiment Station and.
Brice AR; the Department of Chemistry, Clemson University, Clemson, South Carolina 29634.
Dominy BN; the Department of Chemistry, Clemson University, Clemson, South Carolina 29634.
Cao W; From the Department of Genetics and Biochemistry, South Carolina Experiment Station and wgc@clemson.edu.

J Biol Chem ; 289(26): 18413-26, 2014 Jun 27.

Article em En | MEDLINE | ID: mdl-24838246

Assuntos

Thermus thermophilus/enzimologia; Uracila-DNA Glicosidase/química; Uracila-DNA Glicosidase/metabolismo; Sequência de Aminoácidos; Catálise; Reparo do DNA; Hipoxantina/metabolismo; Cinética; Modelos Moleculares; Dados de Sequência Molecular; Alinhamento de Sequência; Especificidade por Substrato; Thermus thermophilus/química; Thermus thermophilus/genética; Uracila/metabolismo; Uracila-DNA Glicosidase/genética; Xantina/metabolismo

Palavras-chave

DNA Damage; DNA Glycosylase; DNA Repair; Deamination; Hypoxanthine; Molecular Modeling; Mutagenesis; Nucleic Acid Enzymology; Uracil; Xanthine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Thermus thermophilus / Uracila-DNA Glicosidase Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article

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