Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis.
Angew Chem Int Ed Engl
; 53(26): 6687-91, 2014 Jun 23.
Article
em En
| MEDLINE
| ID: mdl-24848971
ABSTRACT
Two novel synthetic α2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose (DSLNnT) and α2-6-linked disialyllacto-N-tetraose (DS'LNT), were readily obtained by highly efficient one-pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS'LNT were shown to protect neonatal rats from necrotizing enterocolitis (NEC) and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC in preterm infants.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
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Substâncias Protetoras
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Enterocolite Necrosante
Limite:
Animals
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2014
Tipo de documento:
Article