Photo-induced processes in collagen-hypericin system revealed by fluorescence spectroscopy and multiphoton microscopy.
Biomed Opt Express
; 5(5): 1355-62, 2014 May 01.
Article
em En
| MEDLINE
| ID: mdl-24877000
ABSTRACT
Collagen is the main structural protein and the key determinant of mechanical and functional properties of tissues and organs. Proper balance between synthesis and degradation of collagen molecules is critical for maintaining normal physiological functions. In addition, collagen influences tumor development and drug delivery, which makes it a potential cancer therapy target. Using second harmonic generation, two-photon excited fluorescence microscopy, and spectrofluorimetry, we show that the natural pigment hypericin induces photosensitized destruction of collagen-based tissues. We demonstrate that hypericin-mediated processes in collagen fibers are irreversible and may be used for the treatment of cancer and collagen-related disorders.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Biomed Opt Express
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Taiwan