Access to bifunctionalized biomolecular platforms using oxime ligation.
Carbohydr Res
; 393: 9-14, 2014 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-24879012
ABSTRACT
This paper describes an efficient oxime ligation strategy to prepare multivalent conjugates wherein peptides alone or in combination with carbohydrate or oxime groups were coupled to a cyclopeptide scaffold. To demonstrate the versatility of this approach, two classes of conjugates have been prepared. In one class, we attached two or four peptide sequences to the cyclopeptide core together with free oxime groups, while the second class contains an additional substitution with four or two monosaccharides. The well-defined structure of these conjugates was confirmed by high-resolution mass spectrometry.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Peptídeos
/
Carboidratos
/
Glicoconjugados
Idioma:
En
Revista:
Carbohydr Res
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
República Tcheca