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Release behavior and toxicity profiles towards leukemia (WEHI-3B) cell lines of 6-mercaptopurine-PEG-coated magnetite nanoparticles delivery system.
Dorniani, Dena; Kura, Aminu Umar; Hussein-Al-Ali, Samer Hasan; bin Hussein, Mohd Zobir; Fakurazi, Sharida; Shaari, Abdul Halim; Ahmad, Zalinah.
Afiliação
  • Dorniani D; Materials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
  • Kura AU; Vaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
  • Hussein-Al-Ali SH; Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia ; Faculty of Pharmacy, Isra University, P.O. Box 22, Amman 11622, Jordan.
  • bin Hussein MZ; Materials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
  • Fakurazi S; Vaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
  • Shaari AH; Physics Department, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
  • Ahmad Z; Vaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia ; Chemical Pathology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
ScientificWorldJournal ; 2014: 972501, 2014.
Article em En | MEDLINE | ID: mdl-24895684
The coating of an active drug, 6-mercaptopurine, into the iron oxide nanoparticles-polyethylene glycol (FNPs-PEG) in order to form a new nanocomposite, FPEGMP-2, was accomplished using coprecipitation technique. The resulting nanosized with a narrow size distribution magnetic polymeric particles show the superparamagnetic properties with 38.6 emu/g saturation magnetization at room temperature. Fourier transform infrared spectroscopy and the thermal analysis study supported the formation of the nanocomposite and the enhancement of thermal stability in the resulting nanocomposite comparing with its counterpart in free state. The loading of 6-mercaptopurine (MP) in the FPEGMP-2 nanocomposite was estimated to be about 5.6% and the kinetic experimental data properly correlated with the pseudo-second order model. Also, the release of MP from the FPEGMP-2 nanocomposite shows the sustained release manner which is remarkably lower in phosphate buffered solution at pH 7.4 than pH 4.8, due to different release mechanism. The maximum percentage release of MP from the nanocomposite reached about 60% and 97% within about 92 and 74 hours when exposed to pH 7.4 and 4.8, respectively.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Nanopartículas de Magnetita / Mercaptopurina Limite: Animals Idioma: En Revista: ScientificWorldJournal Assunto da revista: MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Malásia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Nanopartículas de Magnetita / Mercaptopurina Limite: Animals Idioma: En Revista: ScientificWorldJournal Assunto da revista: MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Malásia