Endothelin-converting enzyme 1 and ß-arrestins exert spatiotemporal control of substance P-induced inflammatory signals.

Jensen, Dane D; Halls, Michelle L; Murphy, Jane E; Canals, Meritxell; Cattaruzza, Fiore; Poole, Daniel P; Lieu, TinaMarie; Koon, Hon-Wai; Pothoulakis, Charalabos; Bunnett, Nigel W

Jensen, Dane D; Halls, Michelle L; Murphy, Jane E; Canals, Meritxell; Cattaruzza, Fiore; Poole, Daniel P; Lieu, TinaMarie; Koon, Hon-Wai; Pothoulakis, Charalabos; Bunnett, Nigel W.

Afiliação

Jensen DD; From the Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Halls ML; From the Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Murphy JE; the Department of Surgery, University of California, San Francisco, California 94143.
Canals M; From the Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Cattaruzza F; the Department of Surgery, University of California, San Francisco, California 94143.
Poole DP; From the Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia, the Departments of Anatomy and Neuroscience and.
Lieu T; From the Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Koon HW; the Inflammatory Bowel Disease Research Center, Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, California 90095.
Pothoulakis C; the Inflammatory Bowel Disease Research Center, Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, California 90095.
Bunnett NW; From the Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia, Pharmacology, University of Melbourne, Melbourne 3010, Australia, and Nigel.Bunnett@Monash.edu.

J Biol Chem ; 289(29): 20283-94, 2014 Jul 18.

Article em En | MEDLINE | ID: mdl-24898255

Assuntos

Arrestinas/metabolismo; Ácido Aspártico Endopeptidases/metabolismo; Metaloendopeptidases/metabolismo; Receptores da Neurocinina-1/metabolismo; Substância P/metabolismo; Arrestinas/antagonistas & inibidores; Arrestinas/genética; Ácido Aspártico Endopeptidases/genética; Linhagem Celular; Membrana Celular/metabolismo; Endossomos/metabolismo; Enzimas Conversoras de Endotelina; Transferência Ressonante de Energia de Fluorescência; Técnicas de Silenciamento de Genes; Células HEK293; Humanos; Mediadores da Inflamação/metabolismo; Sistema de Sinalização das MAP Quinases; Metaloendopeptidases/genética; RNA Interferente Pequeno/genética; Receptores Acoplados a Proteínas G/metabolismo; Receptores da Neurocinina-1/genética; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Transdução de Sinais; beta-Arrestinas

Palavras-chave

Arrestins; Cell Signaling; G Protein-coupled Receptor (GPCR); Inflammation; Intracellular Trafficking; Neuropeptide; Receptor Endocytosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metaloendopeptidases / Substância P / Ácido Aspártico Endopeptidases / Receptores da Neurocinina-1 / Arrestinas Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Austrália

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