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Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.
Rudd, Michael T; McCauley, John A; Butcher, John W; Romano, Joseph J; McIntyre, Charles J; Nguyen, Kevin T; Gilbert, Kevin F; Bush, Kimberly J; Holloway, M Katharine; Swestock, John; Wan, Bang-Lin; Carroll, Steven S; DiMuzio, Jillian M; Graham, Donald J; Ludmerer, Steven W; Stahlhut, Mark W; Fandozzi, Christine M; Trainor, Nicole; Olsen, David B; Vacca, Joseph P; Liverton, Nigel J.
Afiliação
  • Rudd MT; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • McCauley JA; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Butcher JW; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Romano JJ; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • McIntyre CJ; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Nguyen KT; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Gilbert KF; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Bush KJ; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Holloway MK; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Swestock J; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Wan BL; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Carroll SS; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • DiMuzio JM; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Graham DJ; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Ludmerer SW; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Stahlhut MW; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Fandozzi CM; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Trainor N; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Olsen DB; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Vacca JP; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Liverton NJ; Departments of Medicinal Chemistry, Molecular Systems, Antiviral Research, and Drug Metabolism, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
ACS Med Chem Lett ; 2(3): 207-12, 2011 Mar 10.
Article em En | MEDLINE | ID: mdl-24900304
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos