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Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.
Eziefula, Alice C; Pett, Helmi; Grignard, Lynn; Opus, Salome; Kiggundu, Moses; Kamya, Moses R; Yeung, Shunmay; Staedke, Sarah G; Bousema, Teun; Drakeley, Chris.
Afiliação
  • Eziefula AC; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Pett H; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Grignard L; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Opus S; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Kiggundu M; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Kamya MR; Infectious Diseases Research Collaboration, Kampala, Uganda Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
  • Yeung S; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Staedke SG; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Bousema T; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Drakeley C; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom teun.bousema@lshtm.ac.uk.
Antimicrob Agents Chemother ; 58(8): 4971-3, 2014 Aug.
Article em En | MEDLINE | ID: mdl-24913169
Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Primaquina / Hemoglobinas / Malária Falciparum / Glucosefosfato Desidrogenase / Antimaláricos Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Primaquina / Hemoglobinas / Malária Falciparum / Glucosefosfato Desidrogenase / Antimaláricos Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido