Isolated hyperthyrotropinemia in childhood obesity and its relation with metabolic parameters.
J Endocrinol Invest
; 37(9): 799-804, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24920280
ABSTRACT
PURPOSE:
The aim of the presented study was to evaluate the prevalence of isolated hyperthyrotropinemia (IH) in obese children and the relation between anthropometric and metabolic parameters.METHODS:
Hospital records of the children, who presented to the Pediatric Endocrinology outpatient clinic of our institution with obesity, and age and gender-matched healthy children, who had undergone thyroid function test for any reason were retrospectively reviewed.RESULTS:
The prevalence of IH was significantly higher in the obese group than in the controls (9.2 and 3.8 %, respectively). Body mass index-standard deviation score (BMI-SDS), thyroid-stimulating hormone (TSH), lipid parameters were significantly different in the obese group than in the control group. A positive correlation between TSH and BMI-SDS and negative correlation between TSH and free T4 (fT4) levels were found in obese subjects. Stepwise multiple linear regression analysis confirmed that BMI-SDS, fT4 and triglyceride levels were the strongest independent variables correlated with TSH level in obese subjects (r (2) = 0.046, p = 0.001).CONCLUSIONS:
IH prevalence is higher in obese children as compared to healthy children and the increase in TSH level correlates negatively with serum fT4 and positively with BMI-SDS and triglyceride levels in obese children.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triglicerídeos
/
Tireotropina
/
Índice de Massa Corporal
/
Dextrotireoxina
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Obesidade Infantil
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
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Female
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Humans
/
Male
Idioma:
En
Revista:
J Endocrinol Invest
Ano de publicação:
2014
Tipo de documento:
Article