Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing.

Saha, Kaustuv; Sambo, Danielle; Richardson, Ben D; Lin, Landon M; Butler, Brittany; Villarroel, Laura; Khoshbouei, Habibeh

Saha, Kaustuv; Sambo, Danielle; Richardson, Ben D; Lin, Landon M; Butler, Brittany; Villarroel, Laura; Khoshbouei, Habibeh.

Afiliação

Saha K; From the Department of Neuroscience and Department of Psychiatry, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida 32611.
Sambo D; From the Department of Neuroscience and Department of Psychiatry, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida 32611.
Richardson BD; From the Department of Neuroscience and Department of Psychiatry, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida 32611.
Lin LM; From the Department of Neuroscience and Department of Psychiatry, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida 32611.
Butler B; From the Department of Neuroscience and Department of Psychiatry, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida 32611.
Villarroel L; From the Department of Neuroscience and Department of Psychiatry, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida 32611.
Khoshbouei H; From the Department of Neuroscience and Department of Psychiatry, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida 32611 habibeh@ufl.edu.

J Biol Chem ; 289(32): 22246-57, 2014 Aug 08.

Article em En | MEDLINE | ID: mdl-24962577

Assuntos

Neurônios Dopaminérgicos/metabolismo; Metanfetamina/metabolismo; Potenciais de Ação/efeitos dos fármacos; Anfetamina/metabolismo; Anfetamina/farmacologia; Animais; Células CHO; Células Cultivadas; Estimulantes do Sistema Nervoso Central/metabolismo; Estimulantes do Sistema Nervoso Central/farmacologia; Cricetinae; Cricetulus; Proteínas da Membrana Plasmática de Transporte de Dopamina/metabolismo; Neurônios Dopaminérgicos/efeitos dos fármacos; Células HEK293; Humanos; Espaço Intracelular/metabolismo; Mesencéfalo/citologia; Mesencéfalo/efeitos dos fármacos; Mesencéfalo/metabolismo; Metanfetamina/farmacologia; Camundongos; Modelos Neurológicos; Técnicas de Patch-Clamp; Transmissão Sináptica/efeitos dos fármacos; Transmissão Sináptica/fisiologia

Palavras-chave

Addiction; Amphetamine; Dopamine Transporter; Methamphetamine; Monoamine Transporter; Neurotransmitter Transport; Patch Clamp Electrophysiology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neurônios Dopaminérgicos / Metanfetamina Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article

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