Dietary cadmium intake and risk of breast, endometrial and ovarian cancer in Danish postmenopausal women: a prospective cohort study.
PLoS One
; 9(6): e100815, 2014.
Article
em En
| MEDLINE
| ID: mdl-24963789
ABSTRACT
PURPOSE:
Cadmium is a human lung carcinogen and possesses estrogen-like activity. This combination of carcinogenic and estrogenic activity makes cadmium a contaminant of high concern for hormone-related cancers. Diet and smoking are the main sources of cadmium exposure. The aim of this study was to investigate the association between dietary cadmium intake and risk of breast, endometrial and ovarian cancer in Danish postmenopausal woman.METHODS:
We estimated dietary cadmium intake in the Diet, Cancer and Health cohort at enrolment 1993-97. The estimates were based on food frequency questionnaires and cadmium contents in all foods. Among 23,815 postmenopausal women we identified 1390 breast, 192 endometrial, and 146 ovarian cancer cases from enrolment through December 31, 2010 using the Danish Cancer Registry. Cox regression was used to analyse the association between dietary cadmium intake and cancer risk.RESULTS:
Mean dietary cadmium intake was 14 µg/day. Cadmium was not associated with breast cancer, incidence rate ratio (IRR)â=â0.99, 95% confidence interval (CI) 0.87-1.13 per 10 µg higher dietary cadmium intake/day; endometrial cancer, IRRâ=â1.08, 95% CI 0.76-1.53; or ovarian cancer, IRRâ=â1.15, 95% CI 0.78-1.70. We found a positive association between cadmium and endometrial cancer for the women with BMI<25 (IRRâ=â1.50, 95% CI 0.94-2.39), whereas an inverse association was seen for the women with BMI≥25 (IRRâ=â0.69, 95% CI 0.42-1.12); p value for interactionâ=â0.02.CONCLUSIONS:
Our study does not indicate that our estimated dietary cadmium intake is associated with hormone-related cancers in women.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Neoplasias da Mama
/
Cádmio
/
Intoxicação por Cádmio
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Neoplasias do Endométrio
/
Suplementos Nutricionais
/
Neoplasias
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Dinamarca