Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates.
Chem Commun (Camb)
; 50(86): 13049-51, 2014 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-24967959
ABSTRACT
Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA
/
RNA Interferente Pequeno
/
Nanoestruturas
Limite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article