Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission.

Wolf, Don P; Mitalipov, Shoukhrat

Wolf, Don P; Mitalipov, Shoukhrat.

Afiliação

Wolf DP; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 Southwest Bond Avenue, Portland, OR 97239, USA; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, 505 Northwest 185(th) Avenue, Beaverton, OR 97006, USA.
Mitalipov S; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 Southwest Bond Avenue, Portland, OR 97239, USA; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, 505 Northwest 185(th) Avenue, Beaverton, OR 97006, USA. Electronic address: mitalipo@ohsu.edu.

Cell Metab ; 20(1): 6-8, 2014 Jul 01.

Article em En | MEDLINE | ID: mdl-24988456

RESUMO

Mitochondrial DNA diseases are relatively common, sometimes devastating, and transmitted exclusively through the egg to children of carrier mothers. A study in Cell by Wang et al. (2014) adds the exciting possibility of a new therapy for preventing mitochondrial disease transmission predicated on the use of polar body genomes in mice.

Assuntos

Doenças Mitocondriais/genética; Doenças Mitocondriais/prevenção & controle; Técnicas de Transferência Nuclear; Oócitos/citologia; Corpos Polares/transplante; Animais; Humanos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oócitos / Doenças Mitocondriais / Técnicas de Transferência Nuclear / Corpos Polares Limite: Animals / Humans Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

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