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Feasibility, safety and efficacy of transcutaneous vagus nerve stimulation in chronic tinnitus: an open pilot study.
Kreuzer, Peter M; Landgrebe, Michael; Resch, Markus; Husser, Oliver; Schecklmann, Martin; Geisreiter, Florian; Poeppl, Timm B; Prasser, Sarah J; Hajak, Goeran; Rupprecht, Rainer; Langguth, Berthold.
Afiliação
  • Kreuzer PM; Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstr. 84, 93053 Regensburg, Germany. Electronic address: peter.kreuzer@medbo.de.
  • Landgrebe M; Department of Psychiatry, Psychosomatics and Psychotherapy, kbo Lech-Mangfall-Klinik Agatharied, Germany.
  • Resch M; Department of Cardiology, Internal Medicine II, University of Regensburg, Regensburg, Germany.
  • Husser O; Department of Cardiology, Internal Medicine II, University of Regensburg, Regensburg, Germany.
  • Schecklmann M; Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstr. 84, 93053 Regensburg, Germany.
  • Geisreiter F; Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstr. 84, 93053 Regensburg, Germany.
  • Poeppl TB; Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstr. 84, 93053 Regensburg, Germany.
  • Prasser SJ; Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstr. 84, 93053 Regensburg, Germany.
  • Hajak G; Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstr. 84, 93053 Regensburg, Germany; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Bezirksklinikum Bamberg, Bamberg, Germany.
  • Rupprecht R; Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstr. 84, 93053 Regensburg, Germany.
  • Langguth B; Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstr. 84, 93053 Regensburg, Germany.
Brain Stimul ; 7(5): 740-7, 2014.
Article em En | MEDLINE | ID: mdl-24996510
ABSTRACT

OBJECTIVES:

Vagus nerve stimulation represents an established treatment strategy for epilepsy and affective disorders. Recently, positive effects were also shown in animals and humans with tinnitus. Here we report the results of an open pilot study exploring feasibility, safety and efficacy of tVNS in the treatment of chronic tinnitus. STUDY

DESIGN:

Fifty patients with chronic tinnitus underwent tVNS in an open single-armed pilot study which was conducted in two phases applying two different stimulating devices (Cerbomed CM02 and NEMOS). Clinical assessment was based on Tinnitus Questionnaire (TQ), Tinnitus Handicap Inventory (THI), Beck Depression Inventory (BDI), WHO Quality of Life, and various numeric rating scales. Primary outcome was defined as change in TQ (baseline vs. final visit in week 24). The study has been registered with clinicaltrials.gov (NCT01176734).

RESULTS:

Primary analysis indicated mean TQ reductions of 3.7 points (phase 1) and 2.8 points (phase 2) significant for the first study phase. Secondary analyses indicated a significant BDI reduction for phase 1 (uncorrected for multiple testing), but no further systematic or significant effects. Adverse events included twitching and pressure at electrode placement site. The occurrence of one hospitalization because of palpations and the development of a left bundle branch block were considered as unrelated to the intervention. Cognitive testing revealed no significant changes.

CONCLUSION:

Our data demonstrate the feasibility of tVNS over a period of 6 months. There was no clinically relevant improvement of tinnitus complaints. Our data suggest tVNS to be considered safe in patients without a history of cardiac disease.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Zumbido / Estimulação Elétrica Nervosa Transcutânea / Estimulação do Nervo Vago Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Stimul Assunto da revista: CEREBRO Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Zumbido / Estimulação Elétrica Nervosa Transcutânea / Estimulação do Nervo Vago Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Stimul Assunto da revista: CEREBRO Ano de publicação: 2014 Tipo de documento: Article