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Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.
Tran, Erin E H; Simmons, James A; Bartesaghi, Alberto; Shoemaker, Charles J; Nelson, Elizabeth; White, Judith M; Subramaniam, Sriram.
Afiliação
  • Tran EE; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Simmons JA; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Bartesaghi A; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Shoemaker CJ; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Nelson E; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • White JM; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Subramaniam S; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA ss1@nih.gov.
J Virol ; 88(18): 10958-62, 2014 Sep.
Article em En | MEDLINE | ID: mdl-25008940
ABSTRACT
The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein lacking the MLD. Our results, which show that the MLD is located at the apex and the sides of each glycoprotein monomer, provide a structural template for analysis of MLD function.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas do Envelope Viral / Doença pelo Vírus Ebola / Ebolavirus Limite: Humans Idioma: En Revista: J Virol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas do Envelope Viral / Doença pelo Vírus Ebola / Ebolavirus Limite: Humans Idioma: En Revista: J Virol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos