Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.
J Virol
; 88(18): 10958-62, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-25008940
ABSTRACT
The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein lacking the MLD. Our results, which show that the MLD is located at the apex and the sides of each glycoprotein monomer, provide a structural template for analysis of MLD function.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas do Envelope Viral
/
Doença pelo Vírus Ebola
/
Ebolavirus
Limite:
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos