Ugi 4-CR Synthesis of γ- and δ-Lactams providing new access to diverse enzyme interactions, a PDB analysis.
Medchemcomm
; 5(7): 949-952, 2014 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-25013719
ABSTRACT
A three step synthesis of N-unsubstituted tetrazolo γ- and δ-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of the N-unsubstituted γ- and δ-lactam fragment reveals a strongly tri-directional hydrogen bond donor acceptor interaction with the amino acids of the binding sites.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Medchemcomm
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Holanda