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Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease.
Zingone, Adriana; Wang, Weixin; Corrigan-Cummins, Meghan; Wu, S Peter; Plyler, Ryan; Korde, Neha; Kwok, Mary; Manasanch, Elisabet E; Tageja, Nishant; Bhutani, Manisha; Mulquin, Marcia; Zuchlinski, Diamond; Yancey, Mary Ann; Roschewski, Mark; Zhang, Yong; Roccaro, Aldo M; Ghobrial, Irene M; Calvo, Katherine R; Landgren, Ola.
Afiliação
  • Zingone A; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Wang W; Hematology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD, USA.
  • Corrigan-Cummins M; Hematology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD, USA.
  • Wu SP; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Plyler R; Hematology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD, USA.
  • Korde N; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Kwok M; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Manasanch EE; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Tageja N; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Bhutani M; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Mulquin M; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Zuchlinski D; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Yancey MA; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Roschewski M; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Zhang Y; Dana-Faber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Boston, MA, USA.
  • Roccaro AM; Dana-Faber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Boston, MA, USA.
  • Ghobrial IM; Dana-Faber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Boston, MA, USA.
  • Calvo KR; Hematology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD, USA.
  • Landgren O; Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Myeloma Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address: landgrec@mskcc.org.
Cytokine ; 69(2): 294-7, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25043675
ABSTRACT
Currently, no reliable biomarkers are available to predict transformation from smoldering myeloma (SMM) to multiple myeloma (MM). Using an ultrasensitive enzyme-linked immunosorbent assay (ELISA) we assessed the levels of a broad range of cytokines and chemokines in the peripheral blood (PB) and bone marrow (BM) supernatant collected from 14 SMM and 38 MM patients and compared to healthy donors. We found significantly increased levels of key cytokines, in particular CXCL8 (IL-8), associated with progressive disease state (controls→SMM→MM). Cytokine profiles were found similar in PB and BM. Five of fourteen SMM patients (36%) progressed to MM. Our findings, although based on a limited number of patients, suggest that serum-based cytokines may have a future role as biomarkers for disease progression and could potentially be assessed as novel targets for treatment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Progressão da Doença / Quimiocinas / Mieloma Múltiplo Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cytokine Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Progressão da Doença / Quimiocinas / Mieloma Múltiplo Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cytokine Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos