[Light-chain deposition disease. Presentation of a case]. / Malattia da depositi di catene leggere (lcdd). Presentazione di un caso.
Pathologica
; 81(1072): 203-11, 1989.
Article
em It
| MEDLINE
| ID: mdl-2505215
ABSTRACT
A case of 66-years-old woman with mild renal failure due to deposition of K light chains on glomerular nodules, is reported. Monoclonal K light chains were found by immunofixation in serum and concentrated urine. Bone marrow examination showed a moderate increase of plasma cells, all stained for K light chains. Amyloid was not identified. No chemotherapy was started. Despite this, in the 15-months follow-up, renal function was preserved; no signs of myeloma, nor of extrarenal involvement were found. Careful follow-up is emphasized. The reason why light chains form amyloidoses or nodular deposits, like diabetic glomerulosclerosis of Kimmelstiel-Wilson, is briefly discussed, together with the differential diagnosis from other nephropathies.
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Base de dados:
MEDLINE
Assunto principal:
Cadeias kappa de Imunoglobulina
/
Glomerulonefrite
/
Hipergamaglobulinemia
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Aged
/
Female
/
Humans
Idioma:
It
Revista:
Pathologica
Ano de publicação:
1989
Tipo de documento:
Article