KLF1: when less is more.

ABSTRACT

In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies. They find that mutations in Krüppel-like factor-1 (KLF1) are significantly more prevalent in patients with ß-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.