Impaired fibrinolytic capacity and tissue plasminogen activator release in patients with restenosis after percutaneous transluminal coronary angioplasty (PTCA).
Thromb Haemost
; 62(2): 772-5, 1989 Sep 29.
Article
em En
| MEDLINE
| ID: mdl-2510351
ABSTRACT
To assess the role of the fibrinolytic system in the pathogenesis of restenosis after percutaneous transluminal coronary angioplasty (PTCA), we determined the components of this system in a retrospective study, including 16 patients with restenosis (gr. A) and 19 patients with long-term success (gr. B). In both groups at baseline fibrinolytic activity (FA) is unchanged, whereas tissue plasminogen activator antigen (tPA-Ag) is significantly increased (gr. A 147.0%; gr. B 139.8%; p less than 0.01). Fibrinolytic capacity (FC) and tPA-Ag release are significantly reduced in the restenosis group (FC 46.5%, p less than 0.05; tPA-Ag release 48.3%, p less than 0.01) compared to normal controls as well as to gr. B (FC 84.3%, p less than 0.05; tPA-Ag release 79.0%, p less than 0.05). Relating to the contact activation system, F XII (79.5%, p less than 0.05) is significantly, and F XI (82.3%) is clearly reduced in gr. A. Protein C (PC) is significantly elevated in gr. B (117.5%, p less than 0.05). There is a negative correlation between plasminogen activator inhibitor (PAI 1) and HDL-cholesterol (r = 0.37, p less than 0.05). It appears, that there is a typical pattern of defective fibrinolysis in patients with restenosis after PTCA and that this might be a pathogenetic factor in the development of restenosis.
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Base de dados:
MEDLINE
Assunto principal:
Angioplastia Coronária com Balão
/
Ativador de Plasminogênio Tecidual
/
Doença das Coronárias
/
Fibrinólise
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Thromb Haemost
Ano de publicação:
1989
Tipo de documento:
Article