Sweet grass protection against oxidative stress formation in the rat brain.
Metab Brain Dis
; 30(1): 183-90, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25108595
ABSTRACT
The aims of this study were to investigate the influences of sweet grass on chronic ethanol-induced oxidative stress in the rat brain. Chronic ethanol intoxication decreased activities and antioxidant levels resulting in enhanced lipid peroxidation. Administration of sweet grass solution to ethanol-intoxicated rats partially normalized the activity activities of Cu,Zn-superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, as well as levels of reduced glutathione and vitamins C, E, and A. Sweet grass also protected unsaturated fatty acids (arachidonic and docosahexaenoic) from oxidations and decreased levels of lipid peroxidation products 4-hydroxynonenal, isoprostanes, and neuroprostanes. The present in vivo study confirms previous in vitro data demonstrating the bioactivity of sweet grass and suggests a possible role for sweet grass in human health protection from deleterious consequences associated with oxidative stress formation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Extratos Vegetais
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Estresse Oxidativo
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Intoxicação Alcoólica
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Poaceae
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Fitoterapia
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Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
Metab Brain Dis
Assunto da revista:
CEREBRO
/
METABOLISMO
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Polônia