Tra2 protein biology and mechanisms of splicing control.
Biochem Soc Trans
; 42(4): 1152-8, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-25110018
ABSTRACT
Tra2 proteins regulate pre-mRNA splicing in vertebrates and invertebrates, and are involved in important processes ranging from brain development in mice to sex determination in fruitflies. In structure Tra2 proteins contain two RS domains (domains enriched in arginine and serine residues) flanking a central RRM (RNA recognition motif). Understanding the mechanisms of how Tra2 proteins work to control splicing is one of the key requirements to understand their biology. In the present article, we review what is known about how Tra2 proteins regulate splicing decisions in mammals and fruitflies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ribonucleoproteínas
/
Proteínas de Ligação a RNA
/
Proteínas de Drosophila
Limite:
Animals
Idioma:
En
Revista:
Biochem Soc Trans
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Reino Unido