4-Substituted quinazoline derivatives as novel EphA2 receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 24(17): 4080-3, 2014 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-25124116
ABSTRACT
Erythropoietin-producing hepatocellular receptor tyrosine kinase subtype A2 (EphA2) is an attractive therapeutic target for suppressing tumor progression. In our efforts to discover novel small molecules to inhibit EphA2, a class of compound based on 4-substituted quinazoline containing 7-(morpholin-2-ylmethoxy) group was identified as a novel hit by high throughput screening campaign. Structural modification of parent quinazoline scaffolds by introducing substituents on aniline displayed potent inhibitory activities toward EphA2.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinazolinas
/
Receptor EphA2
/
Inibidores de Proteínas Quinases
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article