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Fetal origins of malarial disease: cord blood cytokines as risk markers for pediatric severe malarial anemia.
Brickley, Elizabeth B; Wood, Angela M; Kabyemela, Edward; Morrison, Robert; Kurtis, Jonathan D; Fried, Michal; Duffy, Patrick E.
Afiliação
  • Brickley EB; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland Department of Public Health and Primary Care, Strangeways Research Laboratories, University of Cambridge, United Kingdom.
  • Wood AM; Department of Public Health and Primary Care, Strangeways Research Laboratories, University of Cambridge, United Kingdom.
  • Kabyemela E; MOMS Project, Seattle Biomedical Research Institute, Washington Muheza Designated District Hospital, Tanzania.
  • Morrison R; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland MOMS Project, Seattle Biomedical Research Institute, Washington.
  • Kurtis JD; Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Brown University Medical School, Providence.
  • Fried M; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
  • Duffy PE; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
J Infect Dis ; 211(3): 436-44, 2015 Feb 01.
Article em En | MEDLINE | ID: mdl-25139023
ABSTRACT

BACKGROUND:

Severe malarial anemia (SMA) remains a major cause of pediatric illness and mortality in Sub-Saharan Africa. Here we test the hypothesis that prenatal exposures, reflected by soluble inflammatory mediators in cord blood, can condition an individual's susceptibility to SMA.

METHODS:

In a Tanzanian birth cohort (n = 743), we measured cord blood concentrations of tumor necrosis factor (TNF), TNF receptors I and II (TNF-RI and TNF-RII), interleukin (IL)-1ß, IL-4, IL-5, IL-6, IL-10, and interferon gamma (IFN-γ). After adjusting for conventional covariates, we calculated the hazard ratios (HR) for time to first SMA event with log(e) cytokine concentrations dichotomized at the median, by quartile, and per standard deviation (SD) increase.

RESULTS:

Low levels of TNF, TNF-RI, IL-1ß, and IL-5 and high levels of TNF-RII were associated statistically significantly and respectively with approximately 3-fold, 2-fold, 8-fold, 4-fold, and 3-fold increased risks of SMA (Hb < 50 g/L). TNF, TNF-RI, and IL-1ß concentrations were inversely and log-linearly associated with SMA risk; the HR (95% confidence interval [CI]) per 1-SD increase were respectively 0.81 (.65, 1.02), 0.76 (.62, .92), and 0.50 (.40, .62).

CONCLUSIONS:

These data suggest that proinflammatory cytokine levels at birth are inversely associated with SMA risk and support the hypothesis that pediatric malarial disease has fetal origins.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores / Citocinas / Sangue Fetal / Feto / Anemia / Malária Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Infant / Male / Middle aged / Pregnancy Idioma: En Revista: J Infect Dis Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores / Citocinas / Sangue Fetal / Feto / Anemia / Malária Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Infant / Male / Middle aged / Pregnancy Idioma: En Revista: J Infect Dis Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido